Inflammasome-dependent Alarmins Serve as a Tool for Stratification of Neonatal ICU Patients with Infection

Background Diagnosis of neonatal sepsis is complicated due to limited accuracy biochemical, microbiological and phenotypic parameters infection. Hence, early recognition fundamental in reducing the risk sepsis-related diseases mortality. As part innate immune defense mechanisms, inflammasomes sense exogen endogen danger signals thereby effecting secretion inflammatory mediators as well cell death. We first evaluated inflammasome-dependent alarmins Galectin-1 (Gal-1), progranulin (PGRN) resistin septic neonates subsequently examined if surface lipoproteins Staphylococcus aureus (S. aureus) activate toll-like-receptor 2 (TLR2) for release PGRN.